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The effect of micronized frustules. of fossil diatoms (DS) on tumor growth and survival of mice receiving an ip inoculations of either a spontaneous lymphoblastic leukemia (LB) or P-388 lymphocyt-ic leukemia (P-388) was investigated. A multi-dose study was designed, mice receiving 1000,100,10 arid 1 μg of a suspension of DS, either ip or sc on day 1, 4 and 9 after tumor inoculation. With LB the best results were observed when DS were inoculated by the ip route, no effect being observed with the sc route. The best therapeutic effect resulted with 1 μg DS: 33 % of the mice were alive 24 days after tumor inoculation, when all the controls had died. With P-388, only a temporary effect with the 10 μg DS dose was. observed. In no case was it possible to prolong survival. It is concluded that at low doses of DS therapeutic effect is greatest, while toxicity due to SiO2 is greatly reduced.
The effect of micronized frustules. Of fossil diatoms (DS) on tumor growth and survival of mice receiving an ip inoculations of either a spontaneous lymphoblastic leukemia (LB) or P-388 lymphocyt-ic leukemia (P-388) was investigated. A multi -dose study was designed, mice receiving 1000, 100, 10 arid 1 μg of a suspension of DS, either ip or sc on day 1, 4 and 9 after tumor inoculation. With LB the best results were observed when DS were inoculated by the ip route, no effect being observed with the sc route. The best therapeutic effect resulted with 1 μg DS: 33% of the mice were alive for 24 days after tumor inoculation, when all the controls had died. With P-388, only a temporary effect with the 10 μg DS dose was. observed. In no case was it possible to prolong survival. It is concluded that at low doses of DS therapeutic effect is greatest, while toxicity due to SiO2 is greatly reduced.