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流行性出血热发病机理目前尚未完全阐明,国内许多学者通过免疫学研究和组织病理学观察,证明由免疫复合物介导的免疫病理损伤在本病发病机理中起主要作用。但难以解释病程早期伴随严重的病毒血症出现的皮肤,粘膜下血管类组织胺样中毒性改变,因此,我们曾考虑组织胺类介质的释放可能参于流热的免疫学发病机理。新近王文余等证实,流热病程早期病人血浆中IgE 水平显著升高并且与
The pathogenesis of epidemic hemorrhagic fever is not yet fully elucidated. Many scholars in China have demonstrated that immunological pathological injury mediated by immune complexes plays a major role in the pathogenesis of this disease through immunological studies and histopathological observations. However, it is difficult to explain histamine-like toxic changes in the skin and submucosal vessels associated with severe viremia early in the course of the disease. Therefore, we have considered that the release of histamine mediators may be involved in the immunological pathogenesis of fluid flow. Recently, Wang Wenyu and other confirmed that early fluid flow in patients with early IgE plasma levels significantly increased and