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对108例高脂血症患者和128例正常血脂者的载脂蛋白B基因XbaI多态性进行分析,结果显示:X+(第26外显子存在多态切点)基因频率为0.04,远低于西方高加索人种,X-(无多态切点)基因频率为0.96。无论正常血脂组成高血脂组,不同基因型(X+X-和X-X-)的血浆总胆固醇及甘油三酯水平差别均不显著,高血酯组与正常血酯组相比,X+X-与X-X-的发生频率差别也无显著性·冠心病患者69例与对照75例的载脂蛋白B基因EcoRI多态性分析显示全部于第29外显子均存在切点,无多态现象
Analysis of XbaI polymorphism of apolipoprotein B gene in 108 patients with hyperlipidemia and 128 patients with normal blood lipids showed that the gene frequency of X + (exon 26 polymorphism) was 0.04, Much lower than in Western Caucasians, the gene frequency of X- (polymorphic) was 0.96. There was no significant difference in plasma total cholesterol and triglyceride levels between the two genotypes (X + X- and X-X-), no matter the hyperlipidemia group with normal lipid composition, -X- was also not significantly different · The polymorphism analysis of the apolipoprotein B gene EcoRI in 69 cases of CHD patients and 75 cases of CHD showed that all exon 29 had a tangent point with no polymorphism