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1 代谢综合征概念1.1 临床表现代谢综合征(metabolic syndrome)有6个主要表现:腹部肥胖、能引致动脉粥样硬化性血脂异常、高血压、胰岛素抵抗和(或)葡萄糖耐量不正常、前炎症状态和前血栓形成状态。代谢综合征涉及多方面的心血管病危险因子,应予较多关注。在临床上,识别代谢综合征一般根据腹部肥胖、高甘油三酯、低高密度脂蛋白、高血压、高血糖等表现。此外,多个非常规测定的项目如载脂蛋白B升高,小颗粒低密度脂蛋白(low density lipoprotein,LDL)、胰岛素抗性和高胰岛素血症、葡萄糖耐量异常、C-反应蛋白升高,以及多种凝血因子(Ⅰ型纤溶酶原激活物抑制因子和纤维蛋白原)的改变,也被加入到代谢综合征中。会议强调代谢综合征者患者2型糖尿病危险性增高,而糖尿病是心血管病的主要危险因素。
1 Metabolic syndrome concept 1.1 Clinical manifestations Metabolic syndrome (metabolic syndrome) has six main manifestations: abdominal obesity, can cause atherosclerotic dyslipidemia, hypertension, insulin resistance and (or) impaired glucose tolerance, the former inflammation Status and pre-thrombosis status. Metabolic syndrome involves many aspects of cardiovascular risk factors, should pay more attention. Clinically, the identification of metabolic syndrome is generally based on abdominal obesity, high triglycerides, low HDL, high blood pressure, high blood sugar and other performance. In addition, a number of non-routinely measured items such as elevated apolipoprotein B, low density lipoprotein (LDL), insulin resistance and hyperinsulinemia, impaired glucose tolerance, elevated C-reactive protein , As well as a variety of coagulation factors (type I plasminogen activator inhibitor and fibrinogen), are also added to the metabolic syndrome. Meeting stressed that patients with metabolic syndrome increased risk of type 2 diabetes, and diabetes is a major risk factor for cardiovascular disease.