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目的了解河北省2012年脊髓灰质炎(脊灰)疫苗病毒分离率高的邯郸地区人群脊灰中和抗体(NA)水平,为阻断可能发生的疫苗衍生脊灰病毒(VDPV)提供可靠的数据支持。方法调查邯郸市已完成基础免疫1~1.5岁儿童158名;调查<1、1~2、3~4、5~6、7~10、11~14、15~19、≥20岁8个年龄组健康人群168名,采集静脉血标本,测定血清脊灰中和抗体。结果基础免疫儿童脊灰中和抗体Ⅰ、Ⅱ、Ⅲ型阳性率均为100%,抗体几何平均滴度(GMT)分别为1∶467.88、1∶335.46、1∶290.02;健康人群Ⅰ、Ⅱ、Ⅲ型阳性率分别为98.2%、99.4%、95.8%,抗体GMT分别为1∶224.41、1∶177.29、1∶111.43。基础免疫儿童和健康人群间抗体水平差异具有统计学意义(P<0.01),健康人群抗体GMT随年龄增长和免疫后时间延长有逐渐下降趋势,年龄和免疫后时间对抗体有影响,性别间抗体水平差异没有统计学意义。结论邯郸市人群对脊灰病毒形成了良好免疫屏障,对可能发生VDPV及其循环有阻断作用。
Objective To understand the level of poliovirus (NA) in Handan population in Hebei province with high rate of poliomyelitis (poliovirus) vaccine in 2012 and provide reliable data for blocking the potential of vaccine-derived poliovirus (VDPV) stand by. Methods A total of 158 children aged 1 ~ 1.5 years were surveyed in Handan City. A total of 158 children aged <20 years were surveyed at <1,1 ~ 2,3 ~ 4,5 ~ 6,7 ~ 10,11 ~ 14,15 ~ 19 years old. A total of 168 healthy subjects were enrolled in this study. Venous blood samples were collected for the determination of serum poliovirus neutralizing antibodies. Results The positive rates of type I, type II and type III of poliovirus in children with basic immune were all 100%, and the geometric mean antibody titer (GMT) was 1: 467.88,1: 335.46,1: 290.02 respectively. In healthy population, The positive rates of type Ⅲ were 98.2%, 99.4% and 95.8%, respectively. The antibody GMTs were 1: 224.41,1:177.29 and 1: 111.43, respectively. There was a significant difference in antibody levels between children with healthy children and those with healthy children (P <0.01). Antibody GMT in healthy population decreased gradually with the increase of age and time after immunization. Age and immune time had an impact on antibodies, There was no statistical difference between the levels. Conclusion The population of Handan City formed a good immune barrier to poliovirus, blocking the possible occurrence of VDPV and its circulation.