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目的：为了解丙型肝炎患者血清HCVRNA含量与疾病程度及血清丙氨酸转氨酶（ALT）水平的关系。方法：采用荧光聚合酶健反应（PCR）的方法，对105例不同临床类型丙型肝炎患者的血清HCVRNA进行定量检测。结果：丙型肝炎血清HCVRNA含量在103～109．5拷贝／ml之间。无症状HCV感染者血清HCVRNA含量（105.2±1.8拷贝／ml）显著低于急性丙型肝炎患者（107.5±2.4拷贝／ml）、慢性丙型肝炎患者（107.8±3.1拷贝／ml）及肝硬化（107.6±2.5拷贝／ml）。相关分析显示，慢性丙型肝炎病毒血症水平与血清ALT呈显著正相关。结论：高水平的HCV复制可能在肝损害和肝脏疾病的进展中发挥着重要作用。
Objective: To understand the relationship between serum HCVRNA level and disease severity and serum alanine aminotransferase (ALT) level in patients with hepatitis C infection. Methods: Quantitative detection of serum HCV RNA in 105 cases of patients with different clinical types of hepatitis C by fluorescence polymerase chain reaction (PCR) was performed. Results: The serum HCVRNA content of hepatitis C was between 103 and 109.5 copies / ml. Serum HCV RNA levels in asymptomatic HCV-infected individuals (105.2 ± 1.8 copies / ml) were significantly lower than those in patients with acute hepatitis C (107.5 ± 2.4 copies / ml), chronic hepatitis C (107.8 ± 3.1 copies / ml), and cirrhosis 107.6 ± 2.5 copies / ml). Correlation analysis showed that the level of chronic hepatitis C viremia was positively correlated with serum ALT. Conclusions: High levels of HCV replication may play an important role in the progression of liver damage and liver disease.