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目的探讨肺癌袖状切除术与全肺切除术二种手术方式在非小细胞肺癌治疗中的疗效差异。方法将110例确诊为非小细胞肺癌的患者随机分为观察组(袖状切除术组)和对照组(全肺切除术组),各55例,对二组患者的术后相关情况进行追踪比较分析。结果观察组术后肺功能测定[第一秒用力呼气量(FEV1)、用力肺活量(FVC)及自测呼气峰值流速(PEF)]明显优于对照组(P<0.05);观察组术后并发症发生率为12.73%,对照组为30.91%,二组比较差异有统计学意义(P<0.05);观察组术后随访第1、3、5年生存率分别为83.6%、60%、47.3%,对照组分别为65.5%、40%、27.3%,二组术后第1、3、5年生存率比较差异均有统计学意义(P<0.05)。结论袖式切除术治疗非小细胞肺癌能有效改善患者术后肺功能,降低术后并发症发生率及病死率,延长远期生存率,疗效优于全肺切除术,值得推广运用。
Objective To investigate the curative effect of two kinds of operation methods of lung cancer sleeve resection and total pneumonectomy in the treatment of non-small cell lung cancer. Methods One hundred and ten patients diagnosed as non-small cell lung cancer were randomly divided into two groups: observation group (sleeve resection group) and control group (pneumonectomy group), 55 cases each. The patients’ postoperative follow-up was tracked comparative analysis. Results The postoperative lung function tests (FEV1, FVC and PEF) in the observation group were significantly better than those in the control group (P <0.05). The observation group The postoperative complication rate was 12.73% in the control group and 30.91% in the control group, with significant difference between the two groups (P <0.05). The survival rates of the first, third, and fifth postoperative follow-up in the observation group were 83.6% and 60% , 47.3% in the control group, 65.5% in the control group, 40% in the control group and 27.3% in the control group respectively. There was significant difference in the survival rates of the first, third and fifth years after operation between the two groups (P <0.05). Conclusion The cuff resection for non-small cell lung cancer can effectively improve postoperative pulmonary function, reduce the incidence of postoperative complications and mortality, prolong the long-term survival rate, the effect is better than pneumonectomy, it is worth to promote the use of.