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目的探讨盐酸氨溴索治疗老年慢性阻塞性肺疾病伴肺部感染的临床疗效。方法选取2014年4月—2015年12月江苏省常州市德安医院老年科收治的老年慢性阻塞性肺疾病伴肺部感染患者112例,按随机数字表法分成观察组与对照组,各56例。两组患者均给予常规治疗,观察组在常规治疗基础上加用盐酸氨溴索治疗。观察两组患者临床疗效、症状改善时间及不良反应发生情况。结果观察组总有效率高于对照组,差异有统计学意义(P<0.05);两组患者咳嗽、胸闷改善时间比较,差异有统计学意义(P<0.05);两组均未发生严重的药物不良反应。结论盐酸氨溴索治疗老年慢性阻塞性肺疾病伴肺部感染的临床疗效显著,可改善患者临床症状,且不良反应少。
Objective To investigate the clinical efficacy of ambroxol hydrochloride in the treatment of senile chronic obstructive pulmonary disease with pulmonary infection. Methods From April 2014 to December 2015, 112 elderly patients with chronic obstructive pulmonary disease and pulmonary infection admitted to Gerontology Department of De An Hospital, Changzhou, Jiangsu Province were divided into observation group and control group according to random number table example. Two groups of patients were given conventional treatment, the observation group on the basis of conventional treatment plus ambroxol hydrochloride. The clinical efficacy, symptom improvement time and adverse reactions of the two groups were observed. Results The total effective rate of the observation group was higher than that of the control group (P <0.05). There was significant difference between the two groups in the improvement time of cough and chest tightness (P <0.05) medical side effects. Conclusion Ambroxol hydrochloride has significant clinical efficacy in treating chronic obstructive pulmonary disease with pulmonary infection in aged patients, and can improve the clinical symptoms of patients with less adverse reactions.