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目的探讨盐酸多西环素在梅毒中的治疗效果,以期为梅毒的临床治疗提供新的方案。方法 62例梅毒患者,治疗前所有患者均口服醋酸泼尼松片,根据治疗方法不同分为观察组(30例)和对照组(32例)。观察组患者采用盐酸多西环素片,对照组患者采用苄星青霉素,并进行快速血浆反应素环状卡片试验(RPR)复查。随访1年后评价治疗效果。结果随访1年,观察组总有效率为93.33%,对照组总有效率为93.75%,两组总有效率比较差异无统计学意义(χ~2=0.004,P>0.05)。两组3、6、9、12个月RPR阴转率比较差异均无统计学意义(P>0.05);两组显性梅毒3、6、9、12个月RPR阴转率均高于潜伏梅毒(P<0.05)。结论盐酸多西环素治疗梅毒可以取得与苄星青霉素类似的效果,可作为青霉素治疗无效或过敏患者的优先选择。
Objective To explore the therapeutic effect of doxycycline hyclate in syphilis and to provide a new plan for the clinical treatment of syphilis. Methods 62 cases of syphilis patients, all patients before treatment oral prednisone acetate tablets, divided into observation group (30 cases) and control group (32 cases) according to different treatment methods. Patients in the observation group were treated with doxycycline hyclate tablets. Patients in the control group were treated with benzathine penicillin and were followed up for rapid plasma-response cyclic card test (RPR). One year after the follow-up evaluation of the treatment effect. Results One year follow-up, the total effective rate was 93.33% in the observation group and 93.75% in the control group. There was no significant difference in the total effective rate between the two groups (χ ~ 2 = 0.004, P> 0.05). There was no significant difference in RPR overcast rates between the two groups at 3, 6, 9 and 12 months (P> 0.05). The negative conversion rates of RPR at 3, 6, 9 and 12 months in both groups were higher than those in latent Syphilis (P <0.05). Conclusion Doxycycline Hydrochloride can be used to treat syphilis with similar effect to penicillin. It can be used as a priority for those who are ineffective or allergic to penicillin.