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[目的]探讨代谢综合征(MS)患者血清抵抗素与血液流变学的关系。[方法]2004年和2010年,对60例男性MS患者(肥胖组29例,非肥胖组31例)和28例年龄相匹配的男性正常对照者,测定身高、体重、腰围、臀围、血压、血糖、血脂、抵抗素及血液流变学指标,并进行比较分析。[结果]BMI、腰围、臀围、腰臀比、收缩压、舒张压,肥胖MS组均大于对照组(P<0.01);非肥胖MS组均大于对照组(P<0.01)。肥胖MS组的BMI、腰围、臀围均大于非肥胖MS组(P<0.01)。肥胖与非肥胖MS组空腹抵抗素水平均明显高于对照组(P<0.05或P<0.01);空腹血糖、总胆固醇)、甘油三脂、高密度脂蛋白胆固醇、全血高切粘度值、全血中切粘度值、全血低切粘度值、血浆粘度值、红细胞比积、红细胞聚集指数、红细胞刚性指数均高于对照组(P<0.01)。[结论]MS患者血清抵抗素水平增高,导致血液流变性改变。
[Objective] To investigate the relationship between serum resistin and hemorheology in patients with metabolic syndrome (MS). [Methods] In 2004 and 2010, 60 male MS patients (29 in obesity group and 31 in non-obese group) and 28 age-matched male normal controls were enrolled in this study. Height, weight, waist circumference, hip circumference, , Blood glucose, blood lipids, resistin and hemorheology indexes, and comparative analysis. [Results] The BMI, waist circumference, hip circumference, waist-hip ratio, systolic blood pressure, diastolic blood pressure and obesity in MS group were significantly higher than those in control group (P <0.01). BMI, waist circumference and hip circumference in obese MS group were significantly higher than those in non-obese MS group (P <0.01). Fasting resistin levels in obese and non-obese MS groups were significantly higher than those in control group (P <0.05 or P <0.01); fasting blood glucose and total cholesterol, triglyceride, high density lipoprotein cholesterol, Whole blood shear viscosity, whole blood low shear viscosity, plasma viscosity, hematocrit, erythrocyte aggregation index, erythrocyte rigidity index were higher than the control group (P <0.01). [Conclusion] The level of serum resistin in MS patients increases, which leads to the change of hemorrheology.