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本实验在培养的Ｗｉｓｔａｒ大鼠乳鼠心肌细胞上观察了Ｔ—２毒素对膜电位活动的影响及硒的保护作用。结果表明，Ｔ—２毒素（０．１，０．５，５０ｍｇ／Ｌ）使心肌细胞动作电位幅值（ＡＰＡ）、超射（ＯＳ）、阈电位（ＴＰ）、最大舒张电位（ＭＤＰ）及最大除极速率（Ｖ＿（ｍａｘ））显著降低；使复极化时程（ＡＰＤ＿（１０）、ＡＰＤ＿（５０）、ＡＰＤ＿（９０））延长；动作电位发放频率（ＡＰＦ）受到明显抑制。提示Ｔ—２毒素能抑制Ｃａ￣（２＋）、Ｋ￣＋的跨膜转运。０．５ｍｇ／Ｌ硒能使Ｔ—２毒素（１ｍｇ／Ｌ）致心肌细胞动作电位改变的作用明显减小，显示硒具有稳定膜结构与功能的作用。
In this study, the effect of T-2 to membrane potential and the protective effect of selenium on cultured cardiomyocytes of Wistar rats were observed. The results showed that T-2 toxin (0.1,0.5,50 mg / L) significantly increased cardiomyocyte APA, TP, TP and MDP The maximum depolarization rate (V max) decreased significantly. The durations of APD_ (10), APD_ (50) and APD_ (90) were prolonged and the APF was significantly inhibited. Tip T-2 toxin can inhibit Ca ~ (2 +), K ~ + transmembrane transport. 0.5mg / L selenium can T-2 toxin (1mg / L) induced changes in the action potential of myocardial cells was significantly reduced, showing that selenium has a stable membrane structure and function of the role.