【摘 要】
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Exploring the Alzheimer\'s disease neuroepigenome: recent advances and future trends: Alzheimer\'s disease (AD) is a chronic neurodegenerative disease and the most common cause of dementia. After decades of ongoing efforts by scientists, many hallmark
【机 构】
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Department of Biology,Drexel University,Philadelphia,PA,USA
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Exploring the Alzheimer\'s disease neuroepigenome: recent advances and future trends: Alzheimer\'s disease (AD) is a chronic neurodegenerative disease and the most common cause of dementia. After decades of ongoing efforts by scientists, many hallmarks of AD, such as amyloid-β (Aβ) and tau pathologies, have finally been understood. But these milestone discoveries still failed to help us find a cure. In recent years, based on advances in genomics, researchers have discovered more than 20 AD-associated alleles. Three of these alleles can cause autosomal dominant AD: amyloid precursor protein and presenilin 1/2 genes. The rest of these alleles can increase the risk to AD, such as the apolipoprotein E gene. These risk loci implicate Aβ, tau, immunity, and lipid processing, which have helped us accurately understand the complex changes in AD patients\' molecular networks.
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