雌激素在梗阻性肾脏疾病中的保护作用

• 作 者: 茅善华 姜昊文 丁强
• 机 构: 复旦大学附属华山医院泌尿外科,
• 出 处: 临床泌尿外科杂志
• 发表日期: 2013年07期
• 关键词: 肾脏疾病 梗阻性肾病 泌尿系结石 间质炎症反应 肾损伤 肾脏功能 阻性 肾小球滤过率 肾间质纤维化 肾功能损害

泌尿系结石发病率男性显著高于女性,而绝经后女性泌尿系结石发病率显著升高,且以泌尿系结石为主要原因的梗阻性肾脏疾病在绝经后女性中的发病率显著升高。越来越多证据表明,雌激素与梗阻性肾病的进展密切相关。现通过阐述梗阻性肾病发病机制及雌激素与其关系,综述雌激素对梗阻性肾病的保护作用。

The incidence of urolithiasis was significantly higher in males than in females, but the incidence of urolithiasis was significantly increased in postmenopausal women, and the incidence of obstructive kidney disease, a major cause of urolithiasis, was significantly increased in postmenopausal women. There is increasing evidence that estrogen is closely related to the progress of obstructive nephropathy. Through the elucidation of the pathogenesis of obstructive nephropathy and estrogen and its relationship, review the protective effect of estrogen on obstructive nephropathy.