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目的:分析体外受精-胚胎移植(IVF-ET)中不同剂量的曲普瑞林降调节方案的效果,探寻最低而有效的曲普瑞林注射剂量,从而降低IVF-ET的费用。方法:将在银川市妇幼保健院生殖中心行IVF-ET并入选为黄体期长方案的患者随机分为两组,A组(57例)应用长效曲普瑞林,月经第21天注射1.2 mg;B组(71例)应用短效曲普瑞林,于月经周期第21天开始每天注射0.05 mg,直到HCG注射前日。比较A、B两组患者的FSH或/和HMG用量、取卵数、受精率、临床妊娠率及周期总药费。结果:B组患者的FSH或/和HMG用量明显低于A组(P<0.05);两组患者的取卵数、受精率及临床妊娠率比较差异无统计学意义;B组患者的周期总药费明显低于A组(P<0.05)。结论:在IVF-ET中,采用短效曲普瑞林半量注射降调节可减少FSH/HMG用量,降低患者的总药费,且不影响临床妊娠率。
OBJECTIVE: To analyze the effect of different doses of triptorelin regimen in vitro fertilization-embryo transfer (IVF-ET) to explore the minimum and effective dose of triptorelin injection and to reduce the cost of IVF-ET. Methods: The patients who were enrolled in IVF-ET of Reproductive Center of Yinchuan MCH were randomly divided into two groups. Group A (57 cases) received long-acting triptorelin, and on the 21st day of menstruation, they were injected with 1.2 mg; Group B (71 cases) application of short-acting triptorelin, menstrual cycle began on the 21st day of injection of 0.05 mg per day until HCG injection the day before. A and B groups were compared FSH or / and HMG dosage, number of eggs, fertilization rate, clinical pregnancy rate and total cycle costs. Results: The dosage of FSH or / and HMG in group B was significantly lower than that in group A (P <0.05). There was no significant difference in the number of fetus, fertilization and clinical pregnancy between group B and group B Drug costs were significantly lower than those in group A (P <0.05). Conclusion: In IVF-ET, short-acting triptorelin injection can reduce the dosage of FSH / HMG and decrease the total cost of drugs without affecting the clinical pregnancy rate.