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目的观察不稳定型心绞痛(UAP)患者血清肌钙蛋白I(cTnI)含量的变化及其与患者预后的关系,并探讨cTnI与冠状动脉病变程度的关系。方法测定91例UAP患者血清cTnI、磷酸肌酸激酶同工酶(CK-MB)的含量。分析其一般临床特征、冠状动脉病变情况,观察心脏事件发生率,用Logistic回归分析相关因素的影响。结果91例UAP患者中cTnI增高者43例,cTnI增高组与cTnI正常组冠状动脉病变支数、冠状动脉狭窄程度积分比较差异无显著性(P>0.05),通过对心脏事件相关因素的分析,cTnI增高是发生心脏事件的独立危险因素,其相对危险度的估计值为15.82(P<0.01)。结论血清cTnI是UAP患者危险度分层及判断预后的重要生化指标。
Objective To investigate the changes of serum troponin I (cTnI) levels in patients with unstable angina pectoris (UAP) and its relationship with the prognosis of patients, and to explore the relationship between cTnI and the degree of coronary artery lesion. Methods The levels of cTnI and CK-MB in 91 UAP patients were determined. Analysis of its general clinical features, coronary lesions, the incidence of cardiac events observed by Logistic regression analysis of the impact of relevant factors. Results In 91 UAP patients with cTnI increased in 43 cases, cTnI increased group and cTnI normal group coronary artery lesion count, coronary stenosis degree integral was no significant difference (P> 0.05), through the analysis of the factors related to cardiac events, Elevated cTnI is an independent risk factor for cardiac events and its relative risk is estimated to be 15.82 (P <0.01). Conclusion Serum cTnI is an important biochemical indicator of risk stratification and prognosis in patients with UAP.