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作者采用新的敏感方法(改良Salway法)测定Ⅰ型(胰岛素依赖型)及Ⅱ型(非胰岛素依赖型)糖尿病患者的乙酰乙酸(AcAc)及β-羟丁酸(3-OHBA)的血浆浓度,并讨论其临床意义。研究对象①Ⅰ型糖尿病患者117例,年龄7～20岁,均正在接受胰岛素治疗,HbA_1升高,尿C肽排出量<10μg/d。②Ⅱ型糖尿病患者260例、尿C肽排出量>20μg/d,其中1/3病例HbA_1正常,按治疗方法不同,分为饮食、磷脲类及胰岛素治疗组(未接受治疗者28例,包括在饮食组中)。③正常对照组91例,年龄18～65岁。所有病例均测定早餐前空腹血糖、血浆胰岛素、
The authors tested the plasma concentrations of AcAc and 3-OHBA in patients with type 1 (insulin-dependent) and type 2 (non-insulin-dependent) diabetes mellitus using the new sensitive method (modified Salway method) , And discuss its clinical significance. Subjects ① 117 patients with type 1 diabetes mellitus, aged 7 to 20 years old, were undergoing insulin therapy, HbA_1 increased, urinary C-peptide excretion <10μg / d. (2) 260 patients with type II diabetes mellitus, urine C peptide excretion> 20μg / d, of which 1/3 cases of normal HbA_1, according to different treatment methods, divided into diet, phosphate and insulin treatment group In the diet group). ③ normal control group of 91 cases, aged 18 to 65 years. All cases were measured before breakfast fasting blood glucose, plasma insulin,