口服青蒿琥酯对伯氏鼠疟和诺氏猴疟的杀灭效果<英文>

• 作 者: 时云林 李国福 赵京花 杨俊德 丁德本
• 机 构: 军事医学科学院微生物流行病研究所,军事医学科学院微生物流行病研究所,军事医学科学院微生物流行病研究所,军事医学科学院微生物流行病研究所,军事医学科学院微生物流行病研究所 北京 中国 100071,北京
• 出 处: Acta Pharmacologica Sinica
• 发表日期: 1999年08期
• 关键词: 青蒿琥酯 杀灭效果 诺氏疟原虫 抗疟药 artesunate 药效研究 伯氏 原虫血症 裂殖体 parasite

目的:研究青蒿琥酯口服对伯氏鼠疟和诺氏猴疟的血液裂殖体杀灭效果。方法:分别在鼠疟和猴疟模型上采用“4-day试验法”、“28-day试验法”和“7-day试验法”检测了青蒿琥酯和氯喹的药效。结果:口服青蒿琥酯对伯氏鼠疟民K_(173)株的抑制效果低于氯喹,但其原虫血症下降50％、90％和转阴的时间比氯喹快10-15h,对抗株RC/K_(173)的疗效优于氯喹,无交叉抗性,I_(90)仅为1.4。青蒿琥酯和氯喹对诺氏猴疟在31.6,10.0和3.16mg·kg~(-1)剂量组的试验猴全部治愈。结论:口服青蒿琥酯在鼠、猴疟模型上的药效研究为临床研究提供有益参考。

Objective: To study the killing effect of artesunate on blood schizonts of Murine and Non-Marek’s malaria. METHODS: The efficacy of artesunate and chloroquine was tested using the “4-day test”, “28-day test” and “7-day test” on murine malaria and monkey malaria models, respectively. Results: The inhibitory effect of artesunate on malaria K_ (173) strain was lower than that of chloroquine by oral administration of artesunate, but its parasitemia was reduced by 50%, 90% and negative conversion time were 10-15h faster than chloroquine. The efficacy of RC / K_ (173) is superior to that of chloroquine, with no cross-resistance, with a I_ (90) of only 1.4. Artesunate and chloroquine were completely cured in the experimental monkeys of the nymphs of nymphs in the doses of 31.6, 10.0 and 3.16 mg · kg -1. Conclusion: The study of the pharmacodynamics of artesunate on mouse and malaria models provides a useful reference for clinical research.