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目的探讨小儿复方氨基酸和锌佐治小儿难治性腹泻的临床疗效。方法选取2016年1—6月东莞三局医院儿科收治的84例难治性腹泻患儿作为研究对象,采用随机数字表法将其分为观察组与对照组,各42例。对照组患儿接受常规腹泻治疗措施,观察组患儿在对照组基础上联合静脉滴注复方氨基酸注射液,并口服葡萄糖酸锌口服液,比较两组患儿治疗效果、腹泻症状改善情况以及药物应用安全性。结果观察组患儿治疗总有效率为95.2%,明显高于对照组的64.3%,差异有统计学意义(P<0.05);观察组患儿腹泻停止时间、脱水纠正时间均明显短于对照组,差异均有统计学意义(均P<0.05)。两组患儿治疗过程中均未发生严重药物不良反应。结论在常规治疗措施基础上联合应用小儿复方氨基酸和锌可有效提升小儿难治性腹泻临床治疗效果,促进患儿腹泻尽快停止,加速脱水纠正,并且应用安全性较高。
Objective To investigate the clinical efficacy of pediatric compound amino acids and zinc in refractory diarrhea in children. Methods Eighty-four children with refractory diarrhea treated by pediatric department of Dongguan Third Hospital from January to June in 2016 were selected as subjects, and were divided into observation group and control group with 42 cases in each group by random number table method. Children in the control group received routine diarrhea treatment. The children in the observation group were given intravenous infusion of compound amino acid injection and oral zinc gluconate oral solution on the basis of the control group. The therapeutic effect, the improvement of diarrhea symptoms, Application security. Results The total effective rate of observation group was 95.2%, significantly higher than that of control group (64.3%), the difference was statistically significant (P <0.05). The observation group had shorter diarrhea stopping time and dehydration correction time , The differences were statistically significant (all P <0.05). Two groups of children with no serious adverse drug reactions during the course of treatment. Conclusion The combination of routine treatment of children with compound amino acids and zinc can effectively improve the clinical treatment of intractable diarrhea in children, to promote diarrhea in children as soon as possible to speed up the correction of dehydration, and the application of higher safety.