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目的观察连续性血液净化对急性呼吸窘迫综合征(ARDS)的临床疗效及对血浆炎症介质水平的影响。方法将40例ARDS患者分为2组。观察治疗前后APACHEII评分、动脉血气分析、TNF-α、IL-1β的变化。结果治疗组APACHEII评分、动脉血气分析的改善明显优于对照组,且TNF-α和IL-1β表达较对照组降低。差异有统计学意义(P<0.05)。结论连续性血液净化能有效地清除ARDS患者体内的炎症因子,因而更有利于其呼吸功能的改善。
Objective To observe the clinical effect of continuous blood purification on acute respiratory distress syndrome (ARDS) and its effect on plasma inflammatory mediators. Methods 40 ARDS patients were divided into two groups. APACHEII score before and after treatment, arterial blood gas analysis, TNF-α, IL-1β changes. Results The improvement of APACHEII score and arterial blood gas analysis in the treatment group was significantly better than that in the control group, and the expression of TNF-α and IL-1β in the treatment group was lower than that in the control group. The difference was statistically significant (P <0.05). Conclusion Continuous blood purification can effectively remove the inflammatory factors in patients with ARDS, which is more conducive to the improvement of respiratory function.