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目的:比较血清肌钙蛋白(cTnT)与肌酸肌酶(CK)及心肌型肌酸激酶同功酶(CK-MB)在诊断急性心肌梗塞(AMI)中的价值。方法:采用酶联免疫吸附方法,对36例急性心肌梗塞患者、45例心绞痛(AP)疑有微小心肌损伤(MMD)患者以及38例健康(HP)人进行心脏肌钙蛋白T(cTnT)测定,同时作CK和CK-MB两项酶学指标相比较。结果:AMI组,cTnT、CK及CK-MB三者之间的异常率无明显差别(异常率97%~100%);而AP组,cTnT的异常率为35.5%,明显高于CK异常率的8.9%和CK-MB异常率的13.3%。与健康组相比,AP组的cTnT测定的水平明显高于对照组水平(P<0.001)。结论:对于不同程度的急性缺血性心肌损伤的诊断,cTnT较CK及CK-MB,具有更高的灵敏度及特异性。
Objective: To compare the value of serum cTnT, creatine kinase (CK) and myocardial creatine kinase (CK-MB) in the diagnosis of acute myocardial infarction (AMI). METHODS: Cardiac troponin T (cTnT) was measured in 36 patients with acute myocardial infarction, 45 patients with suspected myocardial damage (MMD) with angina pectoris (AP), and 38 healthy individuals by enzyme-linked immunosorbent assay , At the same time as CK and CK-MB two enzymatic indicators compared. Results: There was no significant difference in AMI, cTnT, CK and CK-MB (abnormal rate was 97% ~ 100%), while the abnormal rate of cTnT in AP was 35.5%, which was significantly higher than that of CK Of 8.9% and CK-MB abnormal rate of 13.3%. Compared with the healthy group, the level of cTnT in the AP group was significantly higher than that in the control group (P <0.001). Conclusion: For the diagnosis of acute ischemic myocardial injury, cTnT has higher sensitivity and specificity than CK and CK-MB.