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目的:研究抗环瓜氨酸肽(cyclic citrullinated peptide,CCP)在类风湿性关节炎(rheumatoid arthritis,RA)诊断中的临床应用。方法:以确诊的类风湿关节炎(RA)患者50例为研究对象,其它结缔组织疾病(connec tivetissue disease,CTD)患者50例作为对照,测定血清抗CCP抗体及类风湿因子(rheumatoid factor,RF)水平,观察抗CCP抗体诊断RA的敏感度、特异度、阳性预测值、阴性预测值。结果:抗CCP抗体在RA组阳性率最高;诊断RA,抗CCP抗体的敏感度和特异度、阳性预测值、阴性预测值:为74.0%、97.0%、92.5%、88.2%;RF为86.0%、58.0%、50.6%、89.2%。结论:抗CCP抗体诊断RA有较高的特异度,可用于RA的诊断与鉴别诊断。
Objective: To study the clinical application of cyclic citrullinated peptide (CCP) in the diagnosis of rheumatoid arthritis (RA). Methods: Fifty patients diagnosed as rheumatoid arthritis (RA) were studied. Fifty patients with other connective tissue disease (CTD) were used as control. Serum anti-CCP antibody and rheumatoid factor (RF) ) Levels of anti-CCP antibody to observe the sensitivity, specificity, positive predictive value, negative predictive value. Results: The positive rate of anti-CCP antibody in RA group was the highest. The sensitivity and specificity of RA and anti-CCP antibody were positive predictive value and negative predictive value were 74.0%, 97.0%, 92.5% and 88.2% respectively. The RF was 86.0% , 58.0%, 50.6%, 89.2%. Conclusion: Anti-CCP antibody diagnosis of RA has a high specificity, can be used for the diagnosis and differential diagnosis of RA.