论文部分内容阅读
在心力衰竭的进展过程中 ,心室重构起主要作用。心室重构包括心肌实质重构和心肌间质重构 ,心肌间质重构是指成纤维细胞增生、纤维化以及细胞外基质胶原网的量和组成的变化。基质金属蛋白酶 (MMPs)是一组能特异地降解细胞外基质成分的Zn2 +依赖的酶家族 ,心肌中的MMPs能够降解心脏中所有的基质成分 ,是心肌间质重构中基质降解的推动力量。MMPs的表达与活性受到肿瘤坏死因子 α、白介素 1 β、血管紧张素Ⅱ、内皮素以及金属蛋白酶组织型抑制物等因子的调控。通过直接或间接的方法调节MMPs的活性 ,可以改变心肌间质重构过程 ,从而最终改变心力衰竭的进程
Ventricular remodeling plays a major role in the progression of heart failure. Ventricular remodeling includes myocardial parenchymal remodeling and myocardial interstitial remodeling, and myocardial interstitial remodeling refers to changes in the amount and composition of fibroblast proliferation, fibrosis, and the extracellular matrix collagen network. Matrix metalloproteinases (MMPs) are a family of Zn2 + -dependent enzymes that specifically degrade extracellular matrix components. MMPs in the myocardium are capable of degrading all matrix components in the heart and are the driving forces behind matrix degradation in myocardial interstitial remodeling . The expression and activity of MMPs are regulated by factors such as tumor necrosis factor alpha, interleukin 1 beta, angiotensin II, endothelin, and tissue inhibitor of metalloproteinases. By regulating the activity of MMPs, either directly or indirectly, the process of myocardial interstitial remodeling can be altered to eventually change the course of heart failure