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目的调查健康体检人群血清HbsAg携带情况。方法采用ELISA及化学发光微粒子免疫分析方法对HBV慢性感染者557份高浓度HBsAg(高浓度HBsAg组)和25份低浓度HB-sAg(低浓度HBsAg组)血清标本进行HBV血清标志物检测。结果 9841份血清标本中,ELISA共检出557份A630 nm/A450 nm>2.00,25份0.06≤A630 nm/A450 nm≤2.00。结论血清标本HBsAg定量和ELISA检测结果存在一定差异,需进一步随访,定期复查;低浓度HBsAg因试剂敏感度不足易导致对这部分HBV感染者漏检,则可能进一步造成HBV通过手术、输血等途径传播的严重后果。
Objective To investigate the status of serum HbsAg in healthy people. Methods Serum samples from 557 high-concentration HBsAg (high-concentration HBsAg) and 25 low-concentration HBsAg (low-concentration HBsAg) serum samples from patients with chronic HBV infection were detected by ELISA and chemiluminescence microparticle immunoassay. Results Among 9841 serum samples, 557 copies of A630 nm / A450 nm> 2.00 and 25 copies of 0.06≤A630 nm / A450 nm≤2.00 were detected by ELISA. Conclusions There is a difference between the serum HBsAg quantitation and ELISA test results, which need further follow-up and regular review. Low-concentration HBsAg may lead to undetectable HBV infection due to the lack of sensitivity of the reagent, which may further result in HBV transfusion and other blood transfusions Serious consequences of transmission.