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目的 观察γ 干扰素 (γ IFN)对慢性肝病患者血清肝纤维化指标 (HA、CⅣ、PCⅢ、LN)的影响。方法 治疗组 (6 2例 )给予γ IFN 1MU/d× 30d ,后隔日 1次 ,连续 2个月 ;对照组 (47例 )常规护肝降酶等治疗 3个月。治疗前、后分别检测血清肝纤维化指标 (HA、CⅣ、PCⅢ、LN)。结果 治疗组血清肝纤维化指标(HA、CⅣ、PCⅢ、LN)明显下降 ,差异有显著意义 (P <0 0 1)。结论 γ IFN有较好的抗肝纤维化作用 ,是治疗肝纤维化的有效药物之一。
Objective To observe the effects of γ interferon (IFNγ) on serum levels of hepatic fibrosis (HA, C Ⅳ, PC Ⅲ, LN) in patients with chronic liver disease. Methods The treatment group (62 cases) was treated with γ IFN 1UU / d for 30 days, and every other day for 2 months. The control group (n = 47) received routine therapy such as HEPP for 3 months. Serum levels of liver fibrosis (HA, CⅣ, PCⅢ, LN) were measured before and after treatment. Results The serum levels of hepatic fibrosis (HA, CⅣ, PCⅢ, LN) in the treatment group decreased significantly (P <0.01). Conclusion γ IFN has better anti-hepatic fibrosis and is one of the effective drugs for treating liver fibrosis.