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本研究证明冬虫夏草对体外培养的大鼠肾小管上皮细胞增殖具有明显促进作用,其增殖效应的机制可能与诱导肾小管细胞持续高水平地表达c-myc原癌基因mRNA有关,鉴于急性肾衰治疗的中心环节正在于如何促进损伤、坏死的肾小管细胞再生、修复,因而推测虫草的上述作用可能对于急性肾衰治疗有益,采用虫草治疗庆大霉素诱发的大鼠急性肾损伤,确实具有良好的效果。
This study demonstrated that Cordyceps sinensis promoted the proliferation of rat renal tubular epithelial cells in vitro. The proliferative effect may be related to the induction of high levels of c-myc proto-oncogene mRNA expression in renal tubular cells, in view of acute renal failure treatment. The central part is in the process of how to promote the regeneration and repair of damaged and necrotic tubular cells. Therefore, it is hypothesized that the above effects of Cordyceps may be beneficial for the treatment of acute renal failure. Cordyceps used to treat gentamicin-induced acute kidney injury in rats is indeed good Effect.