论文部分内容阅读
口服药物控释系统的开发由于未能在胃肠道的选择部位逗留和定位而受到约制。减少胃肠道药物转运速率途径之一,是基于采用一种能使药物粘附于胃肠道粘蛋白或上皮细胞表面上的聚合物,从而延长在胃肠道逗留的时间。这种聚合物称为生物粘附剂(Bioadhesive Poly-
Development of an oral drug controlled release system is restricted due to failure to stay and target at selected sites of the gastrointestinal tract. One of the ways to reduce the rate of gastrointestinal drug transport is based on the use of a polymer that allows the drug to adhere to the surface of mucosal or epithelial cells of the gastrointestinal tract, thereby prolonging the length of stay in the gastrointestinal tract. This polymer is called Bioadhesive Poly-