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目的 观察低温海水淹溺濒死大鼠不同时间血气与酸碱代谢的改变 ,分析形成原因和机制 ,为治疗提供理论依据。方法 置动物于 16～ 17℃海水自由游动 ,直至沉入水底 ,呼吸暂停 ;取出后于不同时间测量肛温 ,心脏取血检测血气与酸碱 ,处死动物称取肺湿重计算肺脏 /体重比值。结果 大鼠出海水后的肛温、Pa O2 、Pa SO2 (% )、p H、BE- EC、BE- B、SBC、HCO- 3 及 TCO2 均明显降低 ,而肺脏 /体重比值及 Pa CO2 则显著升高 ;上述指标随时间延长均呈恢复趋势 ,但大多数指标至 6 0 m in仍未回到正常对照水平。结论 低温海水淹溺濒死大鼠 ,主要受低温海水浸泡和低温海水吸入呼吸系统所致侵害 ;前者导致代谢性酸中毒 ,后者则引起低氧血症、高碳酸血症、呼吸性酸中毒及代谢性酸中毒。
Objective To observe the changes of blood gas and acid-base metabolism in rats drowning in low temperature seawater at different times, analyze the causes and mechanism of formation, and provide a theoretical basis for treatment. Methods The animals were allowed to swim freely in the seawater at 16-17 ° C until they were submerged and their apnea stopped. At the same time, the rectal temperature was measured at different times after taking the extract. Heart and blood were taken to measure blood gas and acid and alkali. ratio. Results Rectal temperature, Pa O2, Pa SO2 (%), p H, BE- EC, BE- B, SBC, HCO- 3 and TCO2 in rats after seawater were significantly decreased, while lung / body weight ratio and Pa CO2 Significantly increased; the above indicators showed a trend of recovery with time, but most of the indicators have not returned to the normal control level until 60min. Conclusion Low temperature sea water is drowned in dying rats, mainly due to low temperature seawater immersion and inhalation of respiratory system by low temperature seawater. The former leads to metabolic acidosis, while the latter causes hypoxemia, hypercapnia, respiratory acidosis And metabolic acidosis.