论文部分内容阅读
目的:探讨非小细胞肺癌(NSCLC)组织中的富含脯氨酸蛋白11(PRR11)和沉默信息调节因子2(SIRT2)的表达水平及临床意义。方法:收集山西医科大学第二医院2015年4月至2020年6月病理学检查确诊的100例NSCLC患者癌组织和癌旁组织标本用于免疫组织化学法检测PRR11和SIRT2水平，结合临床资料采用n χ2检验。n 结果:在NSCLC癌组织中PRR11阳性表达率明显高于癌旁组织PRR11阳性表达率(70.00%比8.00%，n χ2＝80.790，n P<0.01)，差异有统计学意义，PRR11表达水平与NSCLC淋巴结转移、组织学分化程度、TNM分期明显相关(n χ2＝9.804、4.972、5.563，n P<0.05)。NSCLC癌组织中SIRT2阳性表达率明显低于癌旁组织SIRT2阳性表达率(37.00%比62.00%，n χ2＝12.501，n P<0.01)，差异有统计学意义，SIRT2表达水平与NSCLC淋巴结转移、TNM分期明显相关(n χ2＝7.032、5.702，n P<0.05)。n 结论:NSCLC癌组织中PRR11呈高表达、NSCLC癌组织中SIRT2呈低表达，检测PRR11和SIRT2的表达有助于预测NSCLC诊治和预后。“,”Objective:To investigate the expression and clinical significance of Proline-rich protein 11 (PRR11) and Silentmating information regulater 2 (SIRT2) in non-small cell lung cancer (NSCLC) tissues.Methods:Envision immunohistochemical method were used to assess the expression of PRR11, SIRT2 in 100 cases of human NSCLC tissues and non-cancerous adjacent lung tissues of patients pathologically confirmed from April 2015 to June 2020 on the Second Hospital of Shanxi Medical University, the statistical analysis of Chi-square test was carried out in combination with clinical data.Results:The expression rate of PRR11 in NSCLC tissues was higher than that of non-cancerous adjacent lung tissues (70.00% vs. 8.00%, n χ2=80.790, n P<0.01), the expressions of PRR11 were associated with NSCLC to lymph node metastasis, tumor node metastasis stage (TNM stage) and histology grade (Respectively,n χ2=9.804, 4.972, 5.563, n P<0.05). The expression rate of SIRT2 in NSCLC tissues was lower than that of non-cancerous adjacent lung tissues (37.00% vs. 62.00%,n χ2=12.501, n P<0.01), the expressions of SIRT2 were associated with NSCLC to lymph node metastasis and TNM stage (Respectively,n χ2=7.032, 5.702, n P<0.05).n Conclusion:Overexpression of PRR11 and downregulation of SIRT2 in NSCLC carcinoma tissues, Joint detection of PRR11 and SIRT2 may be great value for indicating a certain prospect in the diagnosis and treatment of NSCLC.