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目的探讨白细胞介素-17(IL-17)和基质金属蛋白酶-9(MMP-9)在非小细胞肺癌患者癌组织中的表达及其临床意义。方法对经随诊资料完整的术后非小细胞肺癌(NSCLC)患者组织标本60例,采用PV9000二步免疫组化法检测IL-17和MMP-9在癌组织及癌旁组织中的表达。结果 IL-17、MMP-9在非小细胞肺癌组织中表达的阳性率为78.3%、80.0%,在癌旁组织中表达阳性率分别为48.3%、35.0%,癌组织中IL-17与MMP-9的表达高于癌旁组织(P<0.05);不同年龄、性别、病理类型及分化程度的患者其IL-17表达无明显差异(P>0.05);IL-17和MMP-9的阴性表达的患者其3a生存期高于阳性表达组,差异有统计学意义(P<0.05)。结论 IL-17和MMP-9的高表达对非小细胞肺癌的侵袭和转移起着重要作用;IL-17和MMP-9的高表达是肺癌预后不良的指标。
Objective To investigate the expression of interleukin-17 (IL-17) and matrix metalloproteinase-9 (MMP-9) in non-small cell lung cancer and its clinical significance. Methods Sixty patients with postoperative non-small cell lung cancer (NSCLC) were examined by PV9000 immunohistochemistry. The expressions of IL-17 and MMP-9 in cancer and paracancerous tissue were detected by immunohistochemistry. Results The positive rates of IL-17 and MMP-9 in non-small cell lung cancer tissues were 78.3% and 80.0%, respectively. The positive rates of IL-17 and MMP-9 in cancer tissues were 48.3% and 35.0% (P <0.05). There was no significant difference in the expression of IL-17 in different age, sex, pathological type and differentiation (P> 0.05). The positive rates of IL-17 and MMP-9 The survival of patients with 3a expression was higher than the positive expression group, the difference was statistically significant (P <0.05). Conclusion The high expression of IL-17 and MMP-9 plays an important role in the invasion and metastasis of non-small cell lung cancer. The high expression of IL-17 and MMP-9 is an indicator of poor prognosis in lung cancer.