风湿性心脏病免疫致病机理的一种新的假说——依赖巨噬细胞对抗原决定基的选择在导致链球菌风湿性心脏炎诱生期中的作用

• 作 者: Dos Reis G A 叶天星
• 出 处: 国外医学(免疫学分册)
• 发表日期: 1981年05期
• 关键词: 抗原决定基 心脏炎 风湿性心脏病 巨噬细胞 链球菌抗原 心脏损害 链球菌感染 湿热病 致敏 组织相容性

绪言:虽然一般公认在链球菌感染中的异常免疫应答是引起持续性心脏损害可能的原因,但是风湿热的致病机理仍然不明。已知风湿热病人的血清中含有心反应性抗体,并可被A组溶血性链球菌的胞膜特异地吸收,并且与心肌有交叉反应的链球菌抗原结构已被提纯和部分地阐明了特性,可是还没有证据说明这些抗体有致病的作用。虽然有迹象显示致敏的淋巴细胞可能涉及风湿热的致病机理,

INTRODUCTION: Although it is generally accepted that an abnormal immune response in streptococcal infection is a possible cause of persistent cardiac damage, the pathogenesis of rheumatic fever remains unknown. It is known that the serum of patients with rheumatic fever contains cardioreactive antibodies and is specifically absorbed by the membrane of Group A hemolytic streptococcus and the streptococcal antigen structure that cross-reacts with the myocardium has been purified and partially elucidated , But there is no evidence that these antibodies have a pathogenic role. Although there are indications that sensitized lymphocytes may be involved in the pathogenesis of rheumatic fever,