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目的研究纤维蛋白胶包埋顺铂缓释化疗的药动学特点。方法将38例消化道恶性肿瘤患者随机分为2组:纤维蛋白胶包埋顺铂化疗20例为试验组,普通顺铂腹腔化疗18例为对照组。测定并比较两组各个时间点的血、尿顺铂浓度,计算其半衰期(t1/2)、表观分布容积(apparent volume of distribution,Vd)和曲线下面积(area under the curve,AUC)。结果两组患者化疗后的血和尿浓度、t1/2、Vd及AUC差异均有统计学意义(P<0.01)。结论纤维蛋白胶包埋顺铂缓释化疗的t1/2较普通腹腔化疗长,药物主要分布在腹腔局部,提高腹腔局部化疗药物的浓度。
Objective To study the pharmacokinetic characteristics of fibrin glue embedding cisplatin sustained-release chemotherapy. Methods Thirty-eight patients with gastrointestinal cancer were randomly divided into two groups: Fibrin glue embedded Cisplatin chemotherapy in 20 patients as experimental group, Cisplatin as the control group. The blood and urine cisplatin concentrations were measured and compared at each time point to calculate the half-life (t1 / 2), apparent volume of distribution (Vd) and area under the curve (AUC). Results The blood and urine concentrations, t1 / 2, Vd and AUC after chemotherapy in both groups were significantly different (P <0.01). Conclusion The fibrin glue embolized cisplatin sustained-release chemotherapy t1 / 2 longer than normal peritoneal chemotherapy, the drug is mainly distributed in the peritoneal cavity to improve the local intra-abdominal chemotherapy drug concentration.