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目前认为,绒毛膜绒毛取样(CVS)进行孕早期产前诊断是安全有效的选择,但常可出现母体细胞污染(MCC),对试验结果产生继发干扰,产生不良后果,此乃为人们所关心的问题。为了保证潜在的MCC不至干扰正确诊断,许多作者对处理这个问题提出了解决办法,包括:(1)对46,XX核型病例重复进行绒毛膜绒毛取样或随访羊膜穿刺结果;(2)对胎儿性别做超声检查;(3)进行限制性片段长度多态分析;(4)染色体变异体分析等。作者直接对MCC发生率和来自母体蜕膜绒毛仔细检查后的CVS制备进行了研究。核型为46,XX或46,XX/XY的全部CVS标本均用奎吖因染
It is currently believed that chorionic villus sampling (CVS) for the first trimester of pregnancy prenatal diagnosis is a safe and effective option, but often there may be maternal cell contamination (MCC), the test results have secondary interference, resulting in adverse consequences, this is for people issue concerned. In order to ensure that potential MCCs do not interfere with the correct diagnosis, many authors have proposed solutions to this problem, including: (1) repeated chorionic villus sampling or follow-up of amniocentesis in 46, XX karyotype cases; (2) Fetal sex do ultrasound; (3) restriction fragment length polymorphism analysis; (4) chromosome variant analysis. The authors directly studied the incidence of MCC and CVS preparation after careful examination of maternal decidual villi. Karyotype was 46, XX or 46, all CVS specimens of XX / XY were stained with quinacrine