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目的分析单唾液酸四己糖神经节苷脂钠注射液联合高压氧治疗新生儿缺氧缺血性脑病(HIE)对患儿脑血流的影响。方法将184例HIE患儿采用随机数字分组法分为研究组和对照组各92例。研究组患儿采用单唾液酸四己糖神经节苷脂钠注射液联合高压氧进行治疗,对照组患儿采用常规治疗联合高压氧进行治疗,对比2组患儿出生后第1、2、3、5天大脑前动脉(ACA)、大脑中动脉(MCA)、大脑后动脉(PCA)的收缩期峰值流速(Vs)、舒张期流速(Vd)、平均流速(Vm)及阻力指数(RI),观察血流动力情况。结果患儿出生后第1、2天ACA、MCA、PCA的Vs、Vd、Vm低于对照组,RI值高于对照组,差异具有统计学意义(P<0.05);患儿出生后第3、5天,2组ACA、MCA、PCA的Vs、Vd、Vm及RI值比较差异无统计学意义(P>0.05)。结论采用单唾液酸四己糖神经节苷脂钠注射液联合高压氧治疗HIE,可以明显改善患儿脑部血流变化,有助于临床HIE的早期诊断,具有临床应用推广价值。
Objective To analyze the effects of monosialotetrahexosyl ganglioside sodium injection and hyperbaric oxygen on cerebral blood flow in neonates with hypoxic-ischemic encephalopathy (HIE). Methods A total of 184 HIE children were divided into study group and control group by random number grouping method. Children in the study group were treated with monosialotetrahexosyl ganglioside sodium injection combined with hyperbaric oxygenation. The control group was treated with conventional therapy combined with hyperbaric oxygen. Compared with the control group, , Peak systolic velocity (Vs), diastolic velocity (Vd), mean velocity (Vm) and resistance index (RI) of 5 days before anterior cerebral artery (ACA), middle cerebral artery (MCA) and posterior cerebral artery (PCA) , Observe the hemodynamic situation. Results The Vs, Vd and Vm of ACA, MCA and PCA were lower than those of the control group on the 1st and 2nd day after birth, and the RI value was higher than that of the control group (P <0.05). The third , 5 days. The Vs, Vd, Vm and RI of ACA, MCA and PCA in two groups had no significant difference (P> 0.05). Conclusions The treatment of HIE with monosialotetrahexosyl ganglioside sodium injection combined with hyperbaric oxygen can obviously improve the changes of cerebral blood flow in children and contribute to the early diagnosis of clinical HIE, which has the value of clinical application.