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近来,Bor等试图叙述许多低出生体重儿出生时高胆红素血症与以后神经系统发育障碍的关系。然而,同以往的研究一样,仅仅考虑到胆红素的毒性,而没有注意到此色素可能的生物学作用。胆红素是一种奇妙的物质,它从属于一大组称为“胆色素”的复合物,它们广泛分布于动物及蔬菜中。然而,植物中胆色素(藻胆色素、光敏色素)是被公认为起着重要的生理作用,而在无脊椎动物中亦显示出生理学功能。高级脊椎动物的胆色素主要是胆红素和胆绿素,一直被认为是正铁血红素产生的毒性产物。我们认为这个假设应该重新加以探讨。在人类,这些色素的生理学性质还没有完全探明。胆红素生物
Recently, Bor et al attempted to describe the relationship between hyperbilirubinemia at birth in many low birth weight infants and later neurodevelopmental disorders. However, as in previous studies, only the toxicity of bilirubin was taken into account, without noticing the possible biological role of this pigment. Bilirubin is a marvelous substance that belongs to a large group of complexes called “bile pigments,” which are widely distributed in animals and vegetables. However, porphyrins (phycobiliproteins, phytochromes) are considered to play an important physiological role in plants, and physiologically in invertebrates. The biliary pigments of advanced vertebrates, mainly bilirubin and biliverdin, have long been considered the toxic products of heme. We think this assumption should be revisited. In humans, the physiological properties of these pigments have not been fully explored. Bilirubin bio