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胆汁酸是一类由含1~3个羟基的刚性甾体骨架和带有末端羧基的烷烃支链构成的内源性甾体类天然产物,具有多种生物活性。基于胆汁酸骨架的结构修饰及其生物活性研究对于药理学和药物发现具有重要意义。现仅就2013年以来胆汁酸衍生物及其生物活性研究方面的最新进展进行简要综述。
Bile acids are a class of endogenous steroidal natural products consisting of a rigid steroid backbone with 1 to 3 hydroxyl groups and an alkane branch with a terminal carboxyl group, with a variety of biological activities. Structural modifications based on the bile acid backbone and their biological activity are of great importance for pharmacological and drug discovery. The recent progress in the study of bile acid derivatives and their biological activity since 2013 is briefly reviewed.