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敏乐啶(Minoxidil)是一种平滑肌直接松弛剂,具有降低体循环阻力和改善充血性心力衰竭患者心功能的作用.本文旨在评价其对严重慢性充血性心力衰竭病人的血流动力学和临床长期效益.方法:病程在6个月～7年的充血性心力衰竭患者11例,男10例,女1例,平均年龄55岁.其中缺血性心肌病10例,不明原因的心肌病1例.心功能均在Ⅱ～Ⅳ级.所有病例均有心脏增大、肺动脉高压和双侧心力衰竭体征,静息时平均喷血分数24%.在测血流动力学前5天停用各种扩血管药,测定肌酐清除率,并用门电路平衡法心脏血池闪烁显
Minoxidil is a direct smooth muscle relaxant that has the potential to reduce circulatory resistance and improve cardiac function in patients with congestive heart failure.This article aims to evaluate its effects on hemodynamics and clinical outcomes in patients with severe chronic congestive heart failure Long-term benefit.Methods: 11 patients with congestive heart failure of 6 months to 7 years, including 10 males and 1 females, with an average age of 55. Among them, 10 were ischemic cardiomyopathy, 1 with unexplained cardiomyopathy Cases of cardiac function are in grade Ⅱ ~ Ⅳ, all cases have heart enlargement, pulmonary hypertension and bilateral heart failure signs, resting mean ejection fraction of 24% in 5 days before the suspension of blood flow dynamics of various Vasodilator drugs, creatinine clearance was measured, and with the gate balance of heart blood pool was flashing