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为了探讨绝经期促性腺激素 (HMG)促排卵治疗时出现多胎、流产、卵巢过度刺激综合征 (OHSS)的原因、预防及治疗。 1993年 1月～ 1998年 1月我院共收治内分泌失调所致女性不孕妇女 68人并给予HMG促排卵治疗。结果 68例病人共治疗 119个月经周期 ,平均用药 2 49支 ,93个周期有排卵 ( 78 2 % )。妊娠 3 8例 ( 5 5 9% ) ,7例流产 ( 18 4% ) ,13例OHSS( 19 1% ) ,在妊娠病例中 5例多胎 ( 13 1% )。提示HMG对垂体促性腺激素分泌不足者如席汉氏综合征、原发性低促性腺素闭经等治疗效果好。但是在治疗过程中要严密监护 ,防止OHSS、流产的发生 ,对有OHSS、流产、多胎者要及时恰当处理。
To investigate the causes, prevention and treatment of multiple births, miscarriages and ovarian hyperstimulation syndrome (OHSS) in ovulation induction treatment of menopausal gonadotropin (HMG). January 1993 to January 1998 in our hospital were treated endocrine disorders caused by 68 female infertile women and given HMG ovulation therapy. Results A total of 68 patients were treated for 119 menstrual cycles with an average of 299 drugs and 93 cycles of ovulation (78.2%). 38 cases of pregnancy (59.9%), 7 cases of abortion (18.4%), 13 cases of OHSS (19.1%) and 5 cases of multiple births (13.1%) in pregnancy. Prompt HMG pituitary gonadotropin secretion, such as Shethan’s syndrome, primary hypo-gonadotropin amenorrhea and other treatment effect is good. However, in the treatment process should be closely monitored to prevent the occurrence of OHSS, abortion, OHSS, miscarriage, multiple births should be properly handled in a timely manner.