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本文报告了利用放射性配基受体结合法分析测定了甲亢类阴虚和甲低类阳虚模型动物大脑中枢胆碱能M一受体的变化,以及养阴益气中药复方和温补肾阳中药复方对其影响,尝试从细胞生物学水平上对虚证的发病机理和中药复方治疗虚证的机制作些探讨。结果表明,甲亢类阴虚模型大鼠脑中枢胆碱能M一受体数量减少(P<0.05),素和力提高(P<0.05),养阴益气中药复方能提高其数量(P<0.05),降低其亲和力(P<0.05);相反,甲低类阳虚模型免大脑中枢胆碱能M一受体的数量增多(P<0.05),亲和力无明显改变,温补肾阳中药复方能降低其数量。提示中枢胆碱能M一受体的变化,可能是中医阴虚(甲亢)阳虚(甲低)病理生理功能改变的原因之一,中药对此具有纠正调整作用。
This article reports the use of radioligand receptor binding assay to analyze the changes of the central cholinergic M receptor in the brain of Yin deficiency and hypothyroidism in yang deficiency model animals, as well as the combination of nourishing yin and replenishing Chinese herbs and warming up kidney-yang traditional Chinese medicine. The effect of compound prescriptions on the pathogenesis of deficiency syndromes and the production of Chinese medicine compound prescriptions for treating deficiency syndromes were explored at the cell biology level. The results showed that the number of cholinergic M-receptors in the central nervous system of rats with hyperthyroidism was reduced (P<0.05), and the increase in primin and force (P<0.05). The combination of nourishing yin and replenishing qi could increase the number of M-receptors (P<0.05). 0.05), reducing its affinity (P<0.05); conversely, the number of brain-cholinergic M-receptors in the hypothyroidism Yang deficiency model increased (P<0.05), and the affinity did not change significantly. Warming kidney-yang herbal compound energy Reduce its number. It is suggested that the change of the central cholinergic M receptor may be one of the causes of the pathophysiological changes of the yin deficiency (hypothyroidism) deficiency (hypothyroidism) in traditional Chinese medicine. Chinese medicine has a correction and adjustment effect.