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目的 研究较低浓度环氧丙烷对职业接触人群健康的影响情况 ,分析不同的研究指标在环氧丙烷毒性研究和职业人群健康监护工作中的作用和意义 ,为保护接触工人的健康与安全、提高劳动生产率提供科学的依据。方法 选择特大型企业接触环氧丙烷作业的工人为对象 ,分别采用传统的和现代最新的方法研究环氧丙烷对职业接触人群遗传毒性作用 ,同时也对接触者的一般毒性危害作了比较系统的调查。结果 长期接触较低浓度环氧丙烷的作业工人 ,其健康受到了一定程度的危害。主要表现在中枢神经系统症状比较明显。接触组染色体畸变率、淋巴细胞微核试验没有明显改变 ,但姐妹染色单体互换率有明显增加 ,血红蛋白加合物和DNA加合物的实验结果也证实了这一点 ,且具有更为敏感的特性。结论 环氧丙烷对接触者具有一定的遗传毒性。
Objective To study the effects of lower concentrations of propylene oxide on the health of occupationally exposed people and to analyze the significance and significance of different research indicators in the research of propylene oxide toxicity and occupational health monitoring. In order to protect the health and safety of exposed workers, Labor productivity provides a scientific basis. Methods To select the workers who are exposed to propylene oxide in a very large-scale enterprise, the traditional and modern methods were used to study the genotoxic effects of propylene oxide on occupationally exposed people. At the same time, the general toxicity hazards of the contact persons were systematically studied survey. As a result, workers exposed to lower levels of propylene oxide for a long period of time suffered from some health risks. Mainly in the central nervous system symptoms more obvious. Exposure group chromosome aberration rate, lymphocyte micronucleus test did not change significantly, but sister chromatid exchange rate was significantly increased, hemoglobin adduct and DNA adduct experimental results also confirmed this point, and is more sensitive Features. Conclusion Propylene oxide has certain genotoxicity to the contacts.