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目的:评价吗啡分次注射联合间苯三酚治疗肾绞痛的疗效及安全性。方法:患者100例,随机分为2组,每组50例。实验组给予生理盐水100ml+间苯三酚80mg静脉滴注+吗啡9mg静脉分3次推注,对照组给予生理盐水100ml+山莨菪碱10mg静脉滴注+肌注哌替啶50mg。于注射后40min、6h2个时间段观察解痉镇痛效果及其不良反应。结果:治疗40min后,实验组和对照组的显效率分别为46%和38%,两组比较差异无统计学意义(P>0.05)。实验组总有效率和6h内疼痛再发率分别为94%、16%,对照组为80%、34%,两组比较差异有统计学意义(P<0.05);实验组、对照组的不良反应发生率分别为18%、68%,两组比较差异有统计学意义(P<0.01)。结论:吗啡分次注射联合间苯三酚用治疗肾绞痛疗效好,不良反应少,值得临床推广应用。
Objective: To evaluate the efficacy and safety of morphine divided injection combined with phloroglucinol in the treatment of renal colic. Methods: 100 patients were randomly divided into two groups of 50 cases. The experimental group was given saline 100ml + phloroglucinol 80mg intravenous infusion of morphine 9mg intravenously three times injections, the control group was given saline 100ml + anisodamine 10mg intravenous infusion of pethidine 50mg. Spasm and analgesic effects and adverse reactions were observed at 40 min and 6 h after injection. Results: After 40 minutes of treatment, the effective rates of the experimental group and the control group were 46% and 38% respectively, with no significant difference between the two groups (P> 0.05). The total effective rate of the experimental group and the recurrence rate of pain within 6h were 94% and 16%, respectively, which were 80% and 34% in the control group, with significant difference between the two groups (P <0.05) Response rates were 18%, 68%, respectively, with significant difference between the two groups (P <0.01). Conclusion: Morphine sub-injection combined with phloroglucinol is effective in treating renal colic and has few adverse reactions. It is worthy of clinical application.