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Objective: To describe the clinical, laboratory and radiological characteristics and outcomes of moderate-to-severe coronvirus disease 2019 (COVID-19) patients.Methods: We retrospectively analyzed 43 RT-PCR confirmed moderate-to-severe COVID-19 patients who were admitted to a tertiary care center. The primary composite outcomes were admission to intensive care unit, requirement of mechanical ventilation, and death. Results: The median age of the patients was 50 years, and 62.8％ of the patients were male. Out of 43 patients, 15 (34.88％) were categorized as severe. A total of 26 (60.47％) patients had 1 or more comorbidities [diabetes (34.88％) and hypertension (30.23％)]. The median duration from the onset of symptoms to admission was 3 days, and the most common symptoms were dyspnoea (90.7％), cough (79.07％), fever (69.77％), and body ache (46.51％). Leucopenia was presented in 14 (32.56％) patients, lymphopenia in 26 (60.47％) patients, and monocytosis in 7 (16.28％) patients. Besides, 40 (93.02％) patients had bilateral patchy nodular or interstitial infiltration on chest X-ray. The primary outcomes occurred in 20 patients (46.5％), among whom 8 required mechanical ventilation. The patients who had met the primary outcomes were older. They were prone to have at least 1 comorbidity (P=0.004), diabetes (P=0.01), hypertension, higher sequential organ failure assessment score, more tachycardia, lower SpO2, lower PaO2/FiO2, more thrombocytopenia, and more pancytopenia. Conclusions: This retrospective study identified several risk factors for poor outcomes in adults with COVID-19. In particular, older age, tachycardia, high SOFA score, low SpO2, low PaO2/FiO2, presence of comorbidities in form of diabetes and hypertension, thrombocytopenia, and pancytopenia at admission were associated with higher odds of ICU admission, a requirement of mechanical ventilation and in-hospital death.