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目的：评价胃癌caspase-3和bcl-x_L的表达与其组织病理特征及预后的关系。方法：采用免疫组织化学方法对63例随访5年以上胃癌患者的癌组织进行caspase-3和bcl-x_L表达的检测。结果：胃癌caspase-3和bcl-x_L的阳性率分别为71.42％和54.00％。caspase-3和bcl-x_L的表达具有共位性（r=0.4816，P=0.025），两者均在分化好的胃癌中有较强的表达，而在分化差的胃癌表达下降。caspase-3和bcl-x_L的表达与淋巴结转移、TNM分期及患者生存率无关。结论：胃癌caspase-3和bcl-x_L表达随肿瘤分化的降低而下降，caspase-3和bcl-x_L表达的高低不是胃癌的预后因素。
Objective: To evaluate the relationship between the expression of caspase-3 and bcl-x_L in gastric carcinoma and its histopathological features and prognosis. Methods: Immunohistochemistry was used to detect the expression of caspase-3 and bcl-x_L in 63 cases of gastric cancer patients who were followed up for more than 5 years. Results: The positive rates of caspase-3 and bcl-x_L in gastric cancer were 71.42% and 54.00%, respectively. The expression of caspase-3 and bcl-x_L were co-localized (r=0.4816, P=0.025), both of which were strongly expressed in well-differentiated gastric cancer, while the expression of poorly differentiated gastric cancer was decreased. The expression of caspase-3 and bcl-x_L was not related to lymph node metastasis, TNM staging and survival rate. CONCLUSION: The expressions of caspase-3 and bcl-x_L in gastric cancer decrease with the decrease of tumor differentiation. The levels of caspase-3 and bcl-x_L are not the prognostic factors of gastric cancer.