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目的:分析我院抗感染药物近5年的用药现状和耐药菌株耐药率发展趋势,为抗感染药物采购、供应和临床合理应用提供参考。方法:采用我院2008-2012年购药信息,对抗感染药物品种、金额进行排序分析;计算用药频度(DDDs)和绘制细菌耐药趋势图。结果:5年来抗感染药物消耗呈上升趋势,DDDs却逐年下降;细菌耐药率呈缓慢上升趋势,铜绿假单胞菌耐药率呈下降趋势,肺炎克雷伯菌、大肠埃希菌耐药率呈先降后升趋势。结论:抗感染药物临床使用量大,同时近年细菌耐药率呈增长趋势。2008年来由于国家对抗感染药物使用率采取控制措施,使得抗感染药物用量和DDDs下降,促使临床抗感染药物DDDs趋于合理;然而细菌耐药率上升的结果并不随着DDDs降低而降低,揭示细菌耐药率上升是由多种因素共同作用导致,其相关性机制应当进一步深入研究。
OBJECTIVE: To analyze the current situation of anti-infective drugs in our hospital in recent 5 years and the development trend of resistant rate of drug-resistant strains in order to provide references for the procurement, supply and clinical rational use of anti-infective drugs. Methods: According to the pharmacy information of our hospital from 2008 to 2012, we sort and analyze the varieties and amounts of the infected drugs. Calculate the frequency of drug use (DDDs) and draw the trend chart of bacterial drug resistance. Results: The consumption of anti-infective drugs showed an upward trend over the past five years, but DDDs decreased year by year. The drug resistance rate of bacteria showed a slow upward trend, and the drug resistance rate of Pseudomonas aeruginosa showed a decreasing trend. Klebsiella pneumoniae and Escherichia coli were resistant Rate was the first drop after the rise trend. Conclusion: The clinical use of anti-infectives is high, and the rate of bacterial resistance is increasing in recent years. In 2008, due to the state’s control measures on the use of anti-infectives, anti-infectives and DDDs decreased, which led to the rationalization of clinical anti-infectives DDDs. However, the rise of bacterial resistance did not decrease with the decrease of DDDs, The rise of resistance rate is caused by the combination of many factors, and its correlation mechanism should be further studied.