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七十年代初合成的非离子型水溶性三碘造影剂Amipaque,标志着碘造影剂又跨入了一个新时代。继之,又出现了Iopamidol、Ultravist和Omnipaque。在此仅对Iopamidol作一文献综述。一、Iopamidol的药代动力学经血管一次大剂量注入后,血中造影剂浓度迅速达到高峰,2分钟左右迅速下降。血管内造影剂分子透过血管壁进入细胞间液(但不能透过血脑屏障),直至血管内外的渗透压梯度处于平衡状态(约需15～30分钟),随着肾小球的滤过,血中浓度逐渐降
Amipaque, a nonionic water-soluble triiodocarbonate that was synthesized in the early seventies, marked a new era for iodine contrast agents. Then came Iopamidol, Ultravist and Omnipaque. A literature review of Iopamidol is here. First, the pharmacokinetics of Iopamidol After a large dose of blood vessels injected, the concentration of contrast agent in the blood quickly reached its peak, 2 minutes or so decreased rapidly. Intravascular contrast agent molecules through the blood vessel wall into the intercellular fluid (but not through the blood-brain barrier) until the osmotic pressure gradient inside and outside the vessel in equilibrium (about 15 to 30 minutes), with glomerular filtration , The blood concentration gradually decreased