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目的探讨液基细胞学(TCT)与免疫细胞化学技术相联合在卵巢癌腹水鉴别诊断中的临床价值。方法应用液基细胞学技术检测卵巢癌腹水,并同时用普通涂片与之比较。结果 TCT比普通涂片在诊断中有明显优势。对可疑癌细胞且与反应性间皮细胞不易鉴别的疑难腹水标本,TCT制作薄片并做免疫细胞化学,依照鉴别诊断的需要分别标记抗体,结果比单纯TCT诊断恶性腹水的诊断率提高,并根据不同抗体的表达可鉴别腹水中恶性肿瘤细胞是原发性卵巢癌还是转移性腺癌,为临床的治疗提供可靠依据。结论液基细胞学与免疫细胞化学技术相结合在疑难卵巢癌腹水鉴别诊断中有很重要的临床意义,值得推广应用。
Objective To investigate the clinical value of combined liquid-based cytology (TCT) and immunocytochemistry in the differential diagnosis of ascites of ovarian cancer. Methods Liquid-based cytology was used to detect ascites of ovarian cancer and compared with the same smear. Results TCT than the average smear in the diagnosis has obvious advantages. For suspected ascites and difficult to distinguish with reactive mesothelial cells ascites specimens, TCT made thin slices and do immunocytochemistry, in accordance with the needs of differential diagnosis were labeled antibodies, the results than simple TCT diagnosis of malignant ascites increased the diagnostic yield, and according to The expression of different antibodies to identify ascites malignant tumor cells is primary ovarian cancer or metastatic adenocarcinoma, provide a reliable basis for clinical treatment. Conclusion Liquid-based cytology and immunocytochemistry combined in the differential diagnosis of difficult ovarian ascites have very important clinical significance, it is worth to promote the application.