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目的探讨细胞因子在慢性牙周炎(CP)患者龈沟液(GCF)中的含量变化及相关性。方法选取我院就诊的43例慢性牙周病患者的68颗患牙,按照牙周病活动期和静止期诊断标准分为两组,另外以20颗健康成人牙设为对照组,分别收集每颗牙的龈沟液测量细胞因子IL-1、IL-2β、IL-6、TNF-α含量进行对比研究。结果 IL-1、IL-6、TNF-α在活动期患者龈沟液中含量均较对照组明显升高,而IL-2β在活动期患者GCF中含量降低。经治疗转入静止期后,各观测值恢复到与对照组接近水平。结论在慢性牙周病的发生发展过程中,众多细胞因子在其中发挥了重要的作用。对CP患者采取一定的干预措施调节细胞因子的含量,效果明显。
Objective To investigate the changes and correlations of cytokines in GCF of chronic periodontitis (CP) patients. Methods Seventy-six patients with chronic periodontal disease in our hospital were selected and divided into two groups according to the diagnostic criteria of periodontal disease activity and quiescence. Another 20 healthy adult teeth were used as the control group, The levels of cytokines IL-1, IL-2β, IL-6 and TNF-α in gingival crevicular fluid of rats were compared. Results The levels of IL-1, IL-6 and TNF-α in gingival crevicular fluid of active patients were significantly higher than those in control group, while the content of IL-2β in active GCF was decreased. After treatment transferred to quiescence, the observations returned to the level of the control group. Conclusion Many cytokines play an important role in the development of chronic periodontal disease. CP patients take certain interventions to regulate the content of cytokines, the effect is obvious.