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本研究雄性大鼠饲饮１５０ｍｇ／Ｌ的含氟水６个月，常规方法制作睾丸超薄切片，透射电镜观察结果如下：①曲精小管精子形成过程明显损伤，头帽和顶体形成不良，成熟精子生成减少，部分支持细胞滑面内质网扩张，线粒体呈多形性改变，溶酶体增多。②辛丸间质细胞滑面内质网扩张甚至空泡化，线粒体减少，脂滴减少。研究结果表明，氟化钠能导致曲精小管生精细胞损伤，精子生成受阻，间质细胞损伤等改变。
In this study, male rats fed 150mg / L of fluoride-containing water for 6 months, the conventional method of making ultra-thin testicular sections, the results of transmission electron microscopy are as follows: ① The seminiferous tubules spermatogenesis was significantly damaged, head cap and acrosome formation, Mature spermatogenesis was reduced, partially supporting the expansion of endothelium in the glomerulus, mitochondrial pleomorphism and lysosome increase. ② syphilis interstitial cell smooth muscle endoplasmic reticulum expansion or even vacuoles, mitochondria decreased lipid droplets decreased. The results show that sodium fluoride can lead to spermatogonia induced spermatogenic cell damage, blocked sperm production, interstitial cell injury and other changes.