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目的探讨医院内铜绿假单胞菌(PA)对碳青霉烯类抗生素的耐药性,以指导抗菌药物合理使用。方法采集2004至2008年温州医学院附属第一医院病房临床分离PA共3532株,选择亚胺培南(IMP)和美罗培南(MEM)对PA进行药敏实验。结果对IMP和MEM的总耐药率分别是48.44%和46.75%。2005年对IMP的耐药率是60.59%,而2008年的下降到36.79%(P<0.01)。2005年MEM的耐药率是75.23%,而2008年下降到25.95%(P<0.01)。结论 PA对碳青霉烯类的耐药情况严重,对于PA的感染,应在药敏指导下用药。碳青霉烯类抗生素的耐药性已得到明显的控制。
Objective To investigate the resistance of carbapenem antibiotics to Pseudomonas aeruginosa (PA) in hospital to guide the rational use of antibacterials. Methods A total of 3532 clinical isolates of PA were collected from the First Affiliated Hospital of Wenzhou Medical College from 2004 to 2008. The susceptibility test of PA was conducted by selecting imipenem (IMP) and meropenem (MEM). Results The total resistance rates to IMP and MEM were 48.44% and 46.75%, respectively. The resistance rate to IMP in 2005 was 60.59%, while in 2008 it dropped to 36.79% (P <0.01). The resistance rate of MEM was 75.23% in 2005, but dropped to 25.95% in 2008 (P <0.01). Conclusion The resistance of PA to carbapenems is serious. For PA infection, medication should be given under the guidance of drug sensitivity. The resistance of carbapenem antibiotics has been clearly controlled.