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目的探讨血浆抗凝血活酶Ⅲ活性在急性脑梗死患者中的变化及其临床意义。方法选择急性脑梗死者51例,对照组30例,采用发色底物方法、凝固法、凝血酶比浊法分别进行检测,分析血浆抗凝血酶Ⅲ活性(AT-Ⅲ)、血浆凝血酶原时间(PT)、活化部分凝血酶原时间(APTT)、血浆纤维蛋白(Fg)含量;另外选择30例本院门诊健康体检者作为对照组。结果脑梗死患者血浆AT-Ⅲ活性为(87.2±12.9)%,对照组为(95.9±12.8)%,两者比较差异有统计学意义(P<0.05),而PT、APTT、Fg含量比较差异无统计学意义(P>0.05)。结论AT-Ⅲ可作为一种诊断脑梗死的较敏感指标。
Objective To investigate the changes of plasma anticoagulant activity in patients with acute cerebral infarction and its clinical significance. Methods 51 cases of acute cerebral infarction and 30 cases of control group were selected. The chromogenic substrate method, coagulation method and thrombin turbidimetric method were used respectively to detect the activity of antithrombin Ⅲ (AT-Ⅲ), plasma thrombin (PT), partial prothrombin time (APTT), and plasma fibrin (Fg) content. In addition, 30 outpatients were selected as control group. Results The plasma AT-Ⅲ activity in patients with cerebral infarction was (87.2 ± 12.9)% and that in the control group was (95.9 ± 12.8)%, the difference was statistically significant (P <0.05), while the differences of PT, APTT and Fg No statistical significance (P> 0.05). Conclusion AT-Ⅲ can be used as a more sensitive indicator of cerebral infarction.