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目的 检测胰腺癌患者围手术期血浆中内皮素（ｅｎｄｏｔｈｅｌｉｎ ， Ｅ Ｔ） 水平，探讨内皮素与胰腺癌的关系及其临床意义。 方法 应用放射免疫分析法对胰腺癌３４ 例（ 胰头癌２７ 例，胰体尾癌７ 例）患者血浆中 Ｅ Ｔ 水平进行测定，并对其行姑息性手术及根治性手术前后 Ｅ Ｔ 水平的变化进行观察。结果 本组胰头癌患者术前 Ｅ Ｔ 水平〔（５８ ±７） ｎｇ／ Ｌ〕明显高于胰体尾癌组〔（５１ ±４） ｎｇ／ Ｌ， Ｐ＜ ００１〕及正常人组〔（５１ ±６） ｎｇ／ Ｌ， Ｐ＜ ００１〕，在减轻黄疸的手术后胰头癌组降至（５２ ±５） ｎｇ／ Ｌ，胰体尾组降至（５２ ±３） ｎｇ／ Ｌ 与正常水平相近。根治术后，胰头癌组 Ｅ Ｔ 水平为（５５ ±３） ｎｇ／ Ｌ，胰体尾癌组为（５３ ±３）ｎｇ／ Ｌ，均较姑息手术后有所升高，但差异均无显著意义（ Ｐ＞ ００５） 。 结论 胰腺癌患者血浆中内皮素水平升高主要为合并梗阻性黄疸所致，胰腺癌虽可产生内皮素，但其可能仅是参与癌细胞间的调节作用。
Objective To investigate the plasma endothelin (ET) levels in patients with pancreatic cancer during perioperative period, and to explore the relationship between endothelin and pancreatic cancer and its clinical significance. Methods The plasma E T levels in 34 patients with pancreatic cancer (27 pancreatic cancers and 7 pancreatic cancers) were measured by radioimmunoassay and the levels of E T before and after palliative surgery and radical surgery were measured. Change to observe. Results The preoperative E T levels in this group of patients with pancreatic head cancer (58 ± 7 ng/L) were significantly higher than those in the pancreatic body and tail cancer group (51 ± 4) ng/L, P < 0 01) and normal controls. 〔(51 ±6) ng/ L, P< 0 01 〕, decreased to (52 ± 5) ng / L in the pancreatic head cancer group and (52 ± 3) ng in the pancreatic head and tail group after surgery to reduce jaundice. / L is similar to the normal level. After radical resection, the E T level in the pancreatic head cancer group was (55 ±3) ng / L, and the body and tail cancer group was (53 ± 3) ng / L, both of which were higher than those after the palliative surgery. However, no difference was found. Significant (P > 005). Conclusion The increase of plasma endothelin level in patients with pancreatic cancer is mainly caused by obstructive jaundice. Although endothelin may be produced in pancreatic cancer, it may only be involved in the regulation of cancer cells.